Fresh analysis indicates that individuals who discontinue new slimming jabs like semaglutide or tirzepatide may regain reduced body mass far faster than those who halt traditional lifestyle plans.
Research printed in a leading health publication demonstrates that while overweight people can lose a large proportion of their total mass while using the jabs, the weight comes back at an average rate of nearly a kilo each month after stopping.
"Users purchasing these medications should be informed of the risk of fast weight regain when the medication concludes," stated lead investigator Dr. Susan Jebb.
Such speed of regain means a return to pre-treatment mass in about a year and a half.
Comparing Treatments
The research, which examined 37 of studies involving over 9,000 of participants, contrasted the results of these new drugs with conventional dieting.
Researchers note that individuals who lose weight through dieting usually have a slower weight regain—perhaps 0.1 kg a month—post-intervention.
The Reason for the Rapid Regain
Experts believe the mode of action of the injections explains the heightened rebound.
The injections copy a body's own chemical called GLP-1, which controls hunger.
"Sustained high doses of GLP-1 concentrations far above than normal could lead to the body to produce less of its endogenous hormone, and may also diminish sensitivity to its actions," said Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this medication results in hunger is unsuppressed, making excessive eating much more probable."
A Chronic Condition?
The NHS recommend the jabs for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts say that, given the significant potential of relapse, the therapy should be considered ongoing.
This view is reinforced by pharmaceutical companies, who state that the results "emphasize the persistent nature of excess weight," akin to managing diseases like hypertension.
User Accounts
People who have come off the jabs describe a intense return of cravings.
"It was like something flipping and I was suddenly extremely hungry," said one woman.
This challenge is exacerbated if users have not developed lasting dietary or behavioural changes during treatment.
Growing Adoption
Survey data show that a significant number of people in the UK have used weight-loss jabs in the past year, with demand continuing to grow.
- Use is more common among women than men.
- The middle-aged demographic shows the greatest usage rates.
- Many access the medications through private prescriptions rather than the NHS.
In conclusion, clinicians stress that while the jabs are effective agents for shedding pounds, they are not a standalone solution and long-term success hinges on combined lifestyle management.
